In his Lectures on General Pathology, Julius Cohnheim stated “we have here to deal with a molecular change of the vessel walls… comprised under the notion and name of inflammation.” 3 Cohnheim attributed everything to alterations in the endothelium and noted that inflammatory changes did not affect blood as the vessel wall could be modified even if blood were replaced by saline before ligation.
2 It took 40 years for defined theories to attempt to explain what initiates these inflammatory responses. Waller remarked on “the restorative power of blood which immediately closes the aperture” formed by the extravasating leukocytes and proposed that pus has its origin from these colorless extravasated corpuscles. He also noted that as time passed more of them “escaped” into the surrounding tissue while scarcely any red blood cells (RBCs) could be seen outside the vessel. Augustus Waller noted that the trauma caused by the pins and the long exposure to ambient air produced a tongue irritation that triggered the adhesion of lymph-corpuscles onto the vessels of the microcirculation. A few years later the frog-this time its spread tongue-was again central to another milestone microscopic observation.
0 kommentar(er)
